Sarcoidosis can cause Glaucoma, Hypertension and Lesions

Skin[edit]

Main article: Cutaneous manifestations of sarcoidosis

Sarcoidosis involves the skin in between 9 and 37% of persons and is more common in African Americans than in their white counterparts.^[2] The skin is the second most commonly affected organ, after the lungs.^[21] The most common lesions are erythema nodosum, plaques, maculopapular eruptions, subcutaneous nodules, and lupus pernio.^[21] Treatment is not required, since the lesions usually resolve spontaneously in two to four weeks. Although it may be disfiguring, cutaneous sarcoidosis rarely causes major problems.^[2][22][23] Sarcoidosis of the scalp presents with diffuse or patchy hair loss.^[24][25]

Heart[edit]

The frequency of cardiac involvement varies and is significantly influenced by race; in Japan over 25% of persons with sarcoidosis experience symptomatic cardiac involvement, whereas in the US and Europe only about 5% of cases present with cardiac involvement.^[2] Autopsy studies in the US have revealed a frequency of cardiac involvement of about 20–30%, whereas autopsy studies in Japan have shown a frequency of 60%.^[13] The presentation of cardiac sarcoidosis can range from asymptomatic conduction abnormalities to fatal ventricular arrhythmia.^[26] Conduction abnormalities are the most common cardiac manifestations of sarcoidosis among persons and can include complete heart block.^[27] Second to conduction abnormalities, in frequency, are ventricular arrhythmias and occurs in about 23% of persons with cardiac involvement.^[27] Sudden cardiac death, either due to ventricular arrhythmias or complete heart block is a rare complication of cardiac sarcoidosis.^[28][29] Cardiac sarcoidosis can cause fibrosis, granuloma formation or the accumulation of fluid in the interstitium of the heart or a combination of the former two.^[30]

Eye[edit]

Eye involvement occurs in about 10–90% of cases.^[13] Manifestations in the eye include uveitis, uveoparotitis, and retinal inflammation, which may result in loss of visual acuity or blindness.^[31] The most common ophthalmologic manifestation of sarcoidosis is uveitis.^[13][32] The combination of anterior uveitis, parotitis, VII cranial nerve paralysis and fever is called uveoparotid fever or Heerfordt syndrome (D86.8). Development of scleral nodule associated with sarcoidosis have been observed.^[33]